Bucharest University - Physics Department
Prof. Dr. Radu MUTIHAC
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CURRICULUM VITAE

Radu Mutihac

Last name: MUTIHAC

First name: RADU

Place of birth: Bucharest, Romania

Nationality and citizenship: Romanian.

Social status: married, 2 children,

Full home address:

64, Ion Mihalache Blvd., bloc 41, apt. 12, sector 1,

Bucharest 011196, Romania

Phone: +4031-104-8518; +4021-650-3168

Mobile: +4072-702-0772; Fax: +4021-315-9249

E-mail: mutihac@gmail.com

Full address of permanent institution:

Department of Electricity, Solid State & Biophysics, Faculty of Physics, University of Bucharest,

405,AtomistilorStr, PO Box MG-11, Bucharest-Măgurele 077125, Romania,

Phone: +4021-457-4418, +4021-457-4419, Fax: +4021-315-9249,

URL: http://www.fizica.unibuc.ro/mutihac,http://www.fizica.net/mutihac

E-mail:mutihac@gmail.com

Studies:

1. Faculty of Physics, University of Bucharest, 1971-1974; B.Sc. in Physics;
2. Faculty of Physics, University of Bucharest, 1974-1976, M.Sc. in Electronic Physics;
3. Faculty of Physics, University of Bucharest, 1994, Ph.D. in Physics: “Mathematical Modeling and Computer Simulations of Neural Networks”;
4. Faculty of Mathematics, University of Bucharest, 1977-1980, B.Sc. in Informatics.

Scientific training and research:

1. International Centre for Theoretical Physics, Trieste, Italy, 1992-2004;
2. Ecole Polytechnique, Centre de Physique Théorique, Palaiseau, France, 1993;
3. Telecom-Bretagne, Brest-Iroise, France, 1993.
4. EttoreMajorana International Centre for Scientific Culture, Erice, Sicily, Italy, 1995, 1997;
5. Université René Descartes, URA CNRS 1448, Paris, France, 1998;
6. Institut Henri Poincaré, Centre Emile Borel, Paris, France, 1998;
7. Yale University, School of Medicine, Section of Neurobiology, New Haven, CT, USA, 2000-2001;
8. KatholiekeUniversiteit Leuven, School of Medicine, LabovoorNeuro- en Psychofysiologie, Leuven, Belgium, 2001-2002;
9. Johns Hopkins University, MR Research Division, Department of Radiology, School of Medicine, Baltimore, MD, USA, 2003 – 2005.
10. University of New Mexico, School of Medicine, Department of Neurology, Albuquerque, NM 87131, USA, 2010-2011;
11. Walter Reed Army Institute of Research, Division of Psychiatry and Neuroscience, Department of Behavioral Biology, Silver Spring, MD 20910, USA, 2011-2013;
12. National Institutes of Health, National Institute of Deafness and Other Communication Disorders, Department of Intramural Research, Bethesda, MD 20892, USA, 2011-2013;

Selected national and international research projects and grants:

1. Retraining and Updating in Biophysics, TEMPUS Individual Mobility Grant IMG-92-RO-2084, ÉcolePolytechnique, Centre de Physique Théorique, Palaiseau, France, April 4 - July 5, 1993.
2. Graduate Module in Artificial Intelligence: Mathematical Methods for Neural Networks, COMETT-MatariProgramme, Telecom-Bretagne, Brest-Iroise, France, July 21-25, 1993.
3. Pilot Project on Regional Co-operation in Reforming Higher Education, jointly supported by the OECD and EC-PHARE, 1994-1995.
4. PHARE Multi-Country Programme in Higher Education, funded by PHARE supervised by the ETF(European Training Foundation), 1996.
5. Modeling and Simulation of Neural Networks as Coupled Oscillators,Project 3009/1993, item B1, funded by the Ministry of Education and C.N.S.C.U. (National Council of University Scientific Research), 1994-1995.
6. Implementation of a Design Center of Artificial Intelligence Programs with Applications in Higher Education, Project 4009/1995, item B 36, funded by the Ministry of Education and C.N.S.C.U. (National Council of University Scientific Research), 1996.
7. Interactions between Unprotonated Amines and Polyethers, Crown Ethers, and Cryptands,NATO Collaborative Research Grant SRG 941403, 1995 - 1997.
8. Questions Mathématiques en Traitement du Signal et de l'Image,Trimestre de Mathématiques, Institut Henri Poincaré, Centre Emile Borel, Paris, FRANCE, 14 septembre – 18 décembre, 1998.
9. Modeling and simulation of a mitral cell of the olfactory bulb, Research in Neurophysics FULBRIGHT Grant#6, 2000, Yale University, School of Medicine, Section of Neurobiology, New Haven, Connecticut, USA, October 2000 - March 2001.
10. Independent component analysis of functional neuroimaging data, MAPAWAMO European Project, FP5 Programme, QLG3-CT-2000-30161,KatholiekeUniversiteit Leuven, School of Medicine, LabovoorNeuro-en Psychofysiologie, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, BELGIUM; October 2001- September 2002.
11. Exploratory analysis of fMRI data, NIH Grant P41 RR15241, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, and MR Research Division, Department of Radiology, School of Medicine, Johns Hopkins University, 707 N. Broadway, Baltimore, MD 21205, USA, May 2003 - March 2005.
12. Wavelet-based statistical analysis of fMRI activation images, Zavoisky Award, International Society for Magnetic Resonance in Medicine (ISMRM), Berkeley, CA, USA, May, 2006.
13. Independent component analysis of fMRI dataAlgorithms, model selection, and performance, European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), East-Meets-West Grant, Warsaw, Poland, Sept. 2006.
14. Complex platform for medical imaging – Data acquisition, processing, management, and dissemination, PCA-MED, 198/2006, CEEX Module 1, VIASAN, Sept. 1, 2006 - Dec. 10, 2008.
15. Statistical assessment of ICA of neuroimaging data by resampling and hierarchical clustering,European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), East-Meets-West Grant, Vienna, Austria, Oct. 2008.
16. Wavelet shrinkage versus Gaussian spatial filtering of functional MRI data, Zavoisky Award, International Society for Magnetic Resonance in Medicine (ISMRM), Berkeley, CA, USA, April, 2009.
17. Fractal wavelet analysis of the human cerebral cortex, European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), East-Meets-West Grant, Vienna, Austria, Oct. 2009.
18. Spatiotemporal exploratory analysis of fMRI data, Zavoisky Award, International Society for Magnetic Resonance in Medicine (ISMRM), Berkeley, CA, USA, May, 2010.
19. Statistical assessment of exploratory analysis in functional MR neuroimaging, Senior Fulbright Grant #495, University of New Mexico,School of Medicine, Department of Neurology, Albuquerque, NM 87131USA, August 2010 – February 2011.
20. Model-based and data-driven analysis of whole brain EVI demonstrates increased statistical power compared to EPI at 3 T.Zavoisky Award, International Society for Magnetic Resonance in Medicine (ISMRM), Berkeley, CA, USA, May, 2011.
21. Exploratory analysis of functional MR neuroimaging sleep data. The National Research Council (NRC) of the National Academy of Sciences (NAS)Research AssociateshipAward # W81XWH-07-2-0001-0114at the U.S. Army Medical Research and Materiel Command, Walter Reed Army Institute of Research (WRAIR) in Silver Spring, MD 20910, USA and National Institutes of Health (NIH), Bethesda, MD 20892, USA, February 2011 – March 2013.
22. Optimizing correction of geometric distortionin MR images, Zavoisky Award, International Society for Magnetic Resonance in Medicine (ISMRM), Berkeley, CA, USA, May, 2012.
23. Time correlation of EPI versus real-time fMRI time series.Zavoisky Award, International Society for Magnetic Resonance in Medicine (ISMRM), Berkeley, CA, USA, April, 2013.

Governmental employment

1. Deputy General Director, Department of Higher Education, Romanian Ministry of Education, Bucharest, 1993-1994.

Scientific employment:

1. Physicist, Head of Electronic Devices Layout Design Section, Department of Integrated Circuits, Enterprise of Radio Components and Semiconductors, Bucharest-Băneasa, 1976-1981;
2. Professor assistant, Department of Electricity and Biophysics, Faculty of Physics, University of Bucharest, 1981-1991;
3. Lecturer, Department of Electricity and Biophysics, Faculty of Physics, University of Bucharest, 1991-1997;
4. Research Associate, Microprocessor Laboratory, the Abdus Salam International Centre for Theoretical Physics (ICTP), P.O. Box 586, Trieste, 34100, ITALY; X-Ray Project 95A2MC02C jointly funded by the Abdus Salam ICTP andthe United Nations University (UNU), Trieste, Italy, 1995-1997.
5. Associate Professor, Department of Electricity and Biophysics, Faculty of Physics, University of Bucharest, 1997-1999;
6. Professor, Department of Electricity and Biophysics, Faculty of Physics, University of Bucharest, 2000-on;
7. Visiting Professor, KatholiekeUniversiteit Leuven, School of Medicine, LabovoorNeuro- en Psychofysiologie, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, BELGIUM; MAPAWAMO European Project, FP5 Programme, QLG3-CT-2000-30161, 2001-2002;
8. Faculty and Research Associate, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, and Department of Radiology, Johns Hopkins University, 707 N. Broadway, Baltimore, MD 21205, USA, 2003-2005.
9. Senior Research Associate, U.S. Army Medical Research and Materiel Command, Walter Reed Army Institute of Research (WRAIR), Contract #W81XWH-07-2-0001-0114, Silver Spring, MD 20910, U.S.A., February 2011- March 2013.
10. Guest Scientist on Dr. Allen Braun’s protocol 92-DC-0178, National Institutes on Deafness and other Communication Disorders (NIDCD), National Institutes of Health (NIH), 9000 Rockville Pike, Bldg 10 CRC, Room 5D45, MSC-1462,Bethesda, MD 20892-1462, U.S.A., May 10, 2011–April 30,2013.

Main fields of research/competence:

1. Univariate/multivariate imaging data analysis and data mining methods oriented towards large data bases, which include both confirmatory and exploratory approaches:
Hypothesis-driven model-based statistical inference analysis of functional magnetic resonance imaging (fMRI) data, which makes use of spatially extended processes like statistical parametric mapping (SPM), which assumes parametric models at each voxel using the general linear model (GLM) in combination with a temporal convolution model.
Wavelet-based nonparametric regression of fMRI data, which is particularly suited for underlying phenomena with irregular features such as spikes or discontinuities.
Data-driven model-independent component/subspace analysis (ICA). Spatiotemporal ICA simultaneously maximizes the degree of independence over space and time based on the assumption that both spatial and temporal sources are almost independent, which permits recovery of sources that are correlated over time and space.
Fuzzy clustering analysis (FCA) of fMRI time series, with applications in temporal clustering of functional neuroimaging data and validation of ICA decomposition of functional brain imaging.
Analysis of multimodal functional neuroimages.
Analysis of multicontrast functional neuroimages.
Validation of exploratory decompositions of functional neuroimaging data by bootstrap resampling.
Improvement of digital image post-processing existing algorithms in MATLAB.
Refining and developing of novel algorithms for noise reduction, movement correction, and unwarpingofMR images. Evaluation of variability induced by scanner types.
2. Natural image analysis with respect to:
Feature extractionwith the purpose to develop methods for solving difficult high-level image feature extraction and analysis problems;
Image denoising by comparing filtering with a Gaussian kernel and wavelet shrinkage;
Image compression using biorthogonal spline wavelets.
3. Compartmental modeling and computer simulation of various nervous cells and simple neural networks using the NEURON simulation environment (http://www.neuron.yale.edu/):
Development of algorithms in C/C++ inside the NEURON environment for optimization by finding the global minimum/maximum of multidimensional functions;
Extending the conjugate gradient-based algorithms in multidimension to variable metric (quasi-Newton) algorithms for function minimization.
4. Digital X-ray medical image restoration and enhancement based on Bayesian statistics. Development of efficient and robust algorithms implementing Bayesian inference with entropic prior for image processing in:
Digital mammography and early breast cancer detection;
X-ray radiology and computed tomography (CT);
X-ray and MR angiography.
Quantitative and diffusion MRI to assess osteoporosis.

Lectures given in the Department of Electricity and Biophysics:

1. Analysis and Design of Analog and Digital VLSI circuits;
2. Microelectronics;
3. Elements of Automatics;
4. Technologies for Silicon Integrated Electronic Devices;
5. Physical Principles of Medical Imaging;;
6. Imaging Modalities in Medical Physics;
7. System Theory;
8. Digital Signal Processing
9. Modeling and Simulation of Biophysical Systems and Processes;
10. Fundamentals of Neural Networks;
11. Elements of Artificial Intelligence.

Member of the following organizations:

1. Romanian Society of Physics;
2. Romanian US Alumni Association;
3. Romanian Association of Medical Physicists (ARFM);
4. IEEE Fellowof Signal Processing Society and Neural Networks Society, USA (ID #41617054);
5. Organization for Human Brain Mapping (OHBM), Minneapolis, MN 55416 USA (ID #27100);
6. International Society for Magnetic Resonance in Medicine (ISMRM), New York, USA (ID #51004)
7. European Association for International Education (EAIE);
8. International Association of Mathematical Physics (IAMP);
9. Alfred Kastler Foundation, France;
10. Associate of the Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy.

Language competencies:

1. English,
2. French,
3. Italian.

Permanent/temporary scientific referee for thescientific journals:

1. Revue Roumaine de Chimie (RoumanianAcademy);
2. Roumanian Journal of Physics (Roumanian Academy);
3. Roumanian Quarterly Chemical Reviews (Roumanian Academy) – discontinued;
4. Roumanian Reports in Physics (Roumanian Academy);
5. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (Kluwer Academic Publisher, USA);
6. Biotechnology Progress (Center for Biotechnology and Bioengineering, University of Pittsburg, USA);
7. International Journal of Chaos Theory and Applications (Joint publication by the University “Alexandru Ion Cuza”, Jassy, Romania, and the Advanced and Applied Intelligent Technologies Foundation, Lausanne, Switzerland) – discontinued;
8. IEEE Transactions on Image Processing (IEEE, USA);
9. IEEE Transactions on Medical Imaging (IEEE, USA);
10. Journal of Neural Engineering (Institute of Physics Publishing Ltd., London, UK, IOP ID: 113284);
11. Physiological Measurement (Institute of Physics Publishing Ltd., London, UK, IOP ID: 113284);
12. Physics in Medicine and Biology(Institute of Physics Publishing Ltd., London, UK, IOP ID: 113284);
13. International Journal of Adaptive Control and Signal Processing (John Wiley & Sons Ltd., Chichester, New York, Weinheim, Brisbane, Singapore, and Toronto);
14. Neural Networks, Elsevier Editorial System (EES), email: esubmissionsupport@elsevier.com.
15. Artificial Intelligence In Medicine, Elsevier Editorial System (EES), email: http://ees.elsevier.com/aiim

Scientific evaluator/expert/referee:

1. The Romanian –US Fulbright Commission, Bucharest, Romania;
2. CORDIS (The European Commission’s Research and Development Information Service), Brussels);
3. OHBM (Organization for Human Brain Mapping), New York, USA;
4. ISMRM (International Society for Magnetic Resonance in Medicine), Berkeley, USA;
5. WSEAS (World Scientific and Engineering Academy and Society);
6. MEC (Ministry of Education and Research), Bucharest, Romania;
7. CNCSIS (National Council for Scientific Research in Higher Education) Bucharest, Romania;
8. ARACIS (Romanian Agency for Quality Assurance in Higher Education) Bucharest, Romania;

References from:

1. Prof. Peter C. M. Van Zijl, Director, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute and Professor, Johns Hopkins University, Department of Radiology,

707 North Broadway, Baltimore, MD 21205, USA,

Phone: 1-443-923-9510, Fax: 1-443-923-9505,

E-mail: pvanzijl@mri.jhu.edu, URL: http://mri.kennedykrieger.org/sitemap/pvanzijl.html

2. Dr. Thomas Balkin, Head of Behavioral Department, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA.

Phone: 1-301-319-9350, Mobile: 1-410-868-3708, Fax: 1-301-319-9979

E-mail: thomas.balkin@us.army.mil

3. Prof. Stefan Posse, Head of MR Laboratory, 1 University of New Mexico, Department of Neurology, Health Science Center, MSC 10 5620, Albuquerque, NM 87131, USA,

Phone: 1-505-272-3342, 1-505-272-4919, Fax: 1-505-272-6692

E-mail: sposse@unm.edu

4. Dr. Allen Braun, Chief of Language Section, National Institute of Deafness and other Communication Disorders, NIH, Bldg 10, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Phone: 1-301-402-1497, Mobile: 1-301-408-8704, Fax: 1-301-480-5940

E-mail: brauna@nidcd.nih.gov

5. Prof. Julian Chela-Flores, Staff Associate, Abdus Salam Centro Internazionale di Fisica Teorica (ICTP), Main Building, Strada Costiera 11, P.O. Box 586, 34014 Trieste, ITALY (http://www.ictp.it),

Phone: +(39-040)-2240392, Fax: +(39-040)-224.163,

E-mail: chelaf@ictp.trieste.it, URL: http://www.ictp.trieste.it/~chelaf

6. Prof. Marc M. Van Hulle, Catholic University of Leuven, School of Medicine, Laboratory of Neuro- and Psychophysiology, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, BELGIUM,

Tel: +(32-16)-345961, Fax: +(32-16)-345960

E-mail: marc@neuro.kuleuven.be, URL: http://simone.neuro.kuleuven.ac.be

7. Prof. Gordon Shepherd, Yale University, School of Medicine, Section of Neurobiology, C303 SHM, 333 Cedar Street, PO Box 208001, New Haven, CT 06520-8001, USA,

Tel: 1-203-785-4336 / 4334, Fax: 1-203-785-6690,

E-mail: gordon.shepherd@yale.edu

8. Prof. Gheorghe D. Mateescu, Department of Chemistry, Clapp Hall 205,

Case Western Reserve University, Cleveland, Ohio 44106, USA,

Phone: 1-216-368-2589, Fax: 1-216-368-3006,

E-mail: gdm2@cwru.edu

Last updated:

Washington DC, March, 2013

  

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